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FRED HUTCHINSON CANCER RESEARCH CENTER
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Questions 1 What are Human Leukocyte Antigens (HLA) primarily used for by the immune system? 2
In Graft-Versus-Host Disease (GVHD), what specifically happens to the patient's body?
3 According to the text, which HLA markers are most closely connected to a patient's risk of GVHD if they are not matched?
4 On which human chromosome are the genes that code for HLA markers located?
5 How many HLA markers are generally required for a 'good match' in a standard bone marrow transplant versus a cord blood transplant?
6 Why do biological parents and their children always match at least half of their HLA markers?
7 Which of the following factors make finding an HLA match challenging?
8 What is an allogeneic transplant?
9 Why is historical geographic origin (ancestry) important in HLA matching?
10 Explain why an identical twin is a 12 of 12 match for their sibling, while unrelated individuals may only match 2 of 12.